Scheltens P, Fox N, Barkhof F, De Carli C.
Structural magnetic resonance imaging in the practical assessment of dementia: beyond exclusion.
Lancet Neurol. 2002 May;1(1):13-21. Review.
Rombouts SA, Barkhof F, Van Meel CS, Scheltens P.
Alterations in brain activation during cholinergic enhancement with rivastigmine in Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2002 Dec;73(6):665-71.
Burton EJ, Karas G, Paling SM, Barber R, Williams ED, Ballard CG, McKeith IG, Scheltens P, Barkhof F, O'Brien JT. Patterns of cerebral atrophy in dementia with Lewy bodies using voxel-based morphometry.
Neuroimage. 2002 Oct;17(2):618-30.
Karas GB, Burton EJ, Rombouts SA, van Schijndel RA, O'Brien JT, Scheltens P, McKeith IG, Williams D, Ballard C, Barkhof F. A comprehensive study of gray matter loss in patients with Alzheimer's disease using optimized voxel-based morphometry.
Neuroimage. 2003 Apr;18(4):895-907.
Rombouts SA, van Swieten JC, Pijnenburg YA, Goekoop R, Barkhof F, Scheltens P. Related
Loss of frontal fMRI activation in early frontotemporal dementia compared to early AD.
Neurology. 2003 Jun 24;60(12):1904-8.
van Straaten EC, Scheltens P, Knol DL, van Buchem MA, van Dijk EJ, Hofman PA, Karas G, Kjartansson O, de Leeuw FE, Prins ND, Schmidt R, Visser MC, Weinstein HC, Barkhof F. Related
Operational definitions for the NINDS-AIREN criteria for vascular dementia: an interobserver study.
Stroke. 2003 Aug;34(8):1907-12. Epub 2003 Jul 10.
Barkhof F.
Guidelines for brain imaging in vascular dementia clinical trials.
Int Psychogeriatr. 2003;15 Suppl 1:273-6.
de Leeuw FE, Barkhof F, Scheltens P.
White matter lesions and hippocampal atrophy in Alzheimer's disease.
Neurology. 2004 Jan 27;62(2):310-2.
Bastos Leite AJ, van Straaten EC, Scheltens P, Lycklama G, Barkhof F.
Thalamic lesions in vascular dementia: low sensitivity of fluid-attenuated inversion recovery (FLAIR) imaging.
Stroke. 2004 Feb;35(2):415-9. Epub 2004 Jan 15.
De Leeuw FE, Barkhof F, Scheltens P.
Alzheimer's disease--one clinical syndrome, two radiological expressions: a study on blood pressure.
J Neurol Neurosurg Psychiatry. 2004 Sep;75(9):1270-4.
Karas GB, Scheltens P, Rombouts SA, Visser PJ, van Schijndel RA, Fox NC, Barkhof F. Related
Global and local gray matter loss in mild cognitive impairment and Alzheimer's disease.
Neuroimage. 2004 Oct;23(2):708-16.
van Straaten EC, Scheltens P, Barkhof F.
MRI and CT in the diagnosis of vascular dementia.
J Neurol Sci. 2004 Nov 15;226(1-2):9-12. Review.
Barkhof F.
Enlarged Virchow-Robin spaces: do they matter?
J Neurol Neurosurg Psychiatry. 2004 Nov;75(11):1516-7.
Goekoop R, Rombouts SA, Jonker C, Hibbel A, Knol DL, Truyen L, Barkhof F, Scheltens P.
Challenging the cholinergic system in mild cognitive impairment: a pharmacological fMRI study.
Neuroimage. 2004 Dec;23(4):1450-9.
Bastos Leite AJ, Scheltens P, Barkhof F.
Pathological aging of the brain: an overview.
Top Magn Reson Imaging. 2004 Dec;15(6):369-89. Review.
Goekoop R, Duschek EJ, Knol DL, Barkhof F, Netelenbos C, Scheltens P, Rombouts SA. Related
Raloxifene exposure enhances brain activation during memory performance in healthy elderly males; its possible relevance to behavior. Neuroimage. 2005 Mar;25(1):63-75. Epub 2005 Jan 12.
Mulder C, Scheltens P, Barkhof F, Gundy C, Verstraeten RA, de Leeuw FE. Related Articles,
Low vitamin B6 levels are associated with white matter lesions in Alzheimer's disease.
J Am Geriatr Soc. 2005 Jun;53(6):1073-4.
Rombouts SA, Goekoop R, Stam CJ, Barkhof F, Scheltens P.
Delayed rather than decreased BOLD response as a marker for early Alzheimer's disease.
Neuroimage. 2005 Jul 15;26(4):1078-85. Epub 2005 Apr 26.
Korf ES, Scheltens P, Barkhof F, de Leeuw FE.
Blood pressure, white matter lesions and medial temporal lobe atrophy: closing the gap between vascular pathology and Alzheimer's disease? Dement Geriatr Cogn Disord. 2005;20(6):331-7.
de Leeuw FE, Barkhof F, Scheltens P.
Progression of cerebral white matter lesions in Alzheimer's disease: a new window for therapy?
J Neurol Neurosurg Psychiatry. 2005 Sep;76(9):1286-8.
van der Flier WM, van Straaten EC, Barkhof F, Verdelho A, Madureira S, Pantoni L, Inzitari D, Erkinjuntti T, Crisby M, Waldemar G, Schmidt R, Fazekas F, Scheltens P.
Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study.
Stroke. 2005 Oct;36(10):2116-20. Epub 2005 Sep 1.
van der Flier WM, van Straaten EC, Barkhof F, Scheltens P.
NINDS AIREN neuroimaging criteria do not distinguish stroke patients with and without dementia.
Neurology. 2005 Oct 25;65(8):1341. No abstract available.
van der Flier WM, van Straaten EC, Barkhof F, Ferro JM, Pantoni L, Basile AM, Inzitari D, Erkinjuntti T, Wahlund LO, Rostrup E, Schmidt R, Fazekas F, Scheltens P; LADIS study group.
Medial temporal lobe atrophy and white matter hyperintensities are associated with mild cognitive deficits in non-disabled elderly people: the LADIS study.
J Neurol Neurosurg Psychiatry. 2005 Nov;76(11):1497-500.
Rombouts SA, Barkhof F, Goekoop R, Stam CJ, Scheltens P.
Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: an fMRI study.
Hum Brain Mapp. 2005 Dec;26(4):231-9.
Goekoop R, Scheltens P, Barkhof F, Rombouts SA.
Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation--a pharmacological fMRI study. Brain 2006 Jan;129(Pt 1):141-57.Epub Oct 26.
Gootjes L, Bouma A, Van Strien JW, Van Schijndel R, Barkhof F, Scheltens P. Related Articles,
Corpus callosum size correlates with asymmetric performance on a dichotic listening task in healthy aging but not in Alzheimer's disease. Neuropsychologia. 2006;44(2):208-17. Epub 2005 Jun 13.
Bastos Leite AJ, van der Flier WM, van Straaten EC, Scheltens P, Barkhof F.
Infratentorial abnormalities in vascular dementia. Stroke. 2006 Jan;37(1):105-10. Epub 2005 Dec 8.
van de Pol LA, Hensel A, Barkhof F, Gertz HJ, Scheltens P, van der Flier WM.
Hippocampal atrophy in Alzheimer disease: age matters. Neurology. 2006 Jan 24;66(2):236-8.
Pijnenburg YA, Schoonenboom SN, Barkhof F, Knol DL, Mulder C, Van Kamp GJ, Van Swieten JC, Scheltens P. CSF biomarkers in frontotemporal lobar degeneration: relations with clinical characteristics, apolipoprotein E genotype, and neuroimaging.
J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):246-8.
Barkhof F, Scheltens P.
Is the whole brain periventricular?
J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):143-4.
Scheltens P, Barkhof F.
Structural neuroimaging outcomes in clinical dementia trials, with special reference to disease modifying designs. J Nutr Health Aging. 2006 Mar-Apr;10(2):123-8; discussion 129-30. Review.
Yousry TA, Major EO, Ryschkewitsch C, Fahle G, Fischer S, Hou J, Curfman B, Miszkiel K, Mueller-Lenke N, Sanchez E, Barkhof F, Radue EW, Jager HR, Clifford DB.
Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy.
N Engl J Med. 2006 Mar 2;354(9):924-33.
Biessels GJ, De Leeuw FE, Lindeboom J, Barkhof F, Scheltens P.
Increased cortical atrophy in patients with Alzheimer's disease and type 2 diabetes mellitus.
J Neurol Neurosurg Psychiatry. 2006 Mar;77(3):304-7.
van Straaten EC, Fazekas F, Rostrup E, Scheltens P, Schmidt R, Pantoni L, Inzitari D, Waldemar G, Erkinjuntti T, Mantyla R, Wahlund LO, Barkhof F; LADIS Group.
Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study. Stroke. 2006 Mar;37(3):836-40. Epub 2006 Jan 26.
van de Pol LA, Hensel A, van der Flier WM, Visser PJ, Pijnenburg YA, Barkhof F, Gertz HJ, Scheltens P. Hippocampal atrophy on MRI in frontotemporal lobar degeneration and Alzheimer's disease.
J Neurol Neurosurg Psychiatry. 2006 Apr;77(4):439-42. Epub 2005 Nov 23.
Cordonnier C, van der Flier WM, Sluimer JD, Leys D, Barkhof F, Scheltens P.
Prevalence and severity of microbleeds in a memory clinic setting.
Neurology. 2006 May 9;66(9):1356-60.
Pantoni L, Poggesi A, Basile AM, Pracucci G, Barkhof F, Chabriat H, Erkinjuntti T, Ferro JM, Hennerici M, O'Brien J, Schmidt R, Visser MC, Wahlund LO, Waldemar G, Wallin A, Inzitari D; LADIS Study Group. Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: the LADIS (Leukoaraiosis and Disability in the Elderly) Study.
J Am Geriatr Soc. 2006 Jul;54(7):1095-101.
de Leeuw FE, Korf E, Barkhof F, Scheltens P.
White matter lesions are associated with progression of medial temporal lobe atrophy in Alzheimer disease. Stroke. 2006 Sep;37(9):2248-52. Epub 2006 Aug 10.
Ryberg C, Rostrup E, Stegmann MB, Barkhof F, Scheltens P, van Straaten EC, Fazekas F, Schmidt R, Ferro JM, Baezner H, Erkinjuntti T, Jokinen H, Wahlund LO, O'brien J, Basile AM, Pantoni L, Inzitari D, Waldemar G; on behalf of the LADIS study group.
Clinical significance of corpus callosum atrophy in a mixed elderly population.
Neurobiol Aging. 2007 Jun;28(6):955-63.
Bouwman FH, Schoonenboom SN, van der Flier WM, van Elk EJ, Kok A, Barkhof F, Blankenstein MA, Scheltens P.
CSF biomarkers and medial temporal lobe atrophy predict dementia in mild cognitive impairment. Neurobiol Aging. 2007 Jul;28(7):1070-4.
Damoiseaux JS, Beckmann CF, Arigita EJ, Barkhof F, Scheltens P, Stam CJ, Smith SM, Rombouts SA. Reduced resting-state brain activity in the "default network" in normal aging. Cereb Cortex. 2007 Dec 27;
Rombouts SA, Damoiseaux JS, Goekoop R, Barkhof F, Scheltens P, Smith SM, Beckmann CF. Model-free group analysis shows altered BOLD FMRI networks in dementia. Hum Brain Mapp. 2007 Nov 27;
Bastos-Leite AJ, van der Flier WM, van Straaten EC, Staekenborg SS, Scheltens P, Barkhof F. The contribution of medial temporal lobe atrophy and vascular pathology to cognitive impairment in vascular dementia. Stroke. 2007 Dec;38(12):3182-5.
Karas G, Scheltens P, Rombouts S, van Schijndel R, Klein M, Jones B, van der Flier W, Vrenken H, Barkhof F. Precuneus atrophy in early-onset Alzheimer's disease: a morphometric structural MRI study. Neuroradiology. 2007 Dec;49(12):967-76.
Barkhof F, Polvikoski TM, van Straaten EC, Kalaria RN, Sulkava R, Aronen HJ, Niinistö L, Rastas S, Oinas M, Scheltens P, Erkinjuntti T. The significance of medial temporal lobe atrophy: a postmortem MRI study in the very old. Neurology. 2007 Oct 9;69(15):1521-7.
van de Pol LA, van der Flier WM, Korf ES, Fox NC, Barkhof F, Scheltens P. Baseline predictors of rates of hippocampal atrophy in mild cognitive impairment. Neurology. 2007 Oct 9;69(15):1491-7.
Ylikoski R, Jokinen H, Andersen P, Salonen O, Madureira S, Ferro J, Barkhof F, van der Flier W, Schmidt R, Fazekas F, Scheltens P, Waldemar G, Salvadori E, Pantoni L, Inzitari D, Erkinjuntti T; LADIS Study Group. Comparison of the Alzheimer's Disease Assessment Scale Cognitive Subscale and the Vascular Dementia Assessment Scale in differentiating elderly individuals with different degrees of white matter changes. The LADIS Study. Dement Geriatr Cogn Disord. 2007;24(2):73-81.
Mulder C, van der Flier WM, Veerhuis R, Bouwman F, Jakobs C, Verhoeven NM, Barkhof F, Scheltens P, Blankenstein MA. Association between vitamin B6 and white matter hyperintensities in patients with Alzheimer's disease not mediated by homocysteine metabolism. J Am Geriatr Soc. 2007 Jun;55(6):956-8.
van der Flier WM, Barkhof F, Scheltens P. Shifting paradigms in dementia: toward stratification of diagnosis and treatment using MRI. Ann N Y Acad Sci. 2007 Feb;1097:215-24. Review.
Rombouts SA, Scheltens P, Kuijer JP, Barkhof F. Whole brain analysis of T2* weighted baseline FMRI signal in dementia. Hum Brain Mapp. 2007 Dec;28(12):1313-7
Schoonenboom NS, van der Flier WM, Blankenstein MA, Bouwman FH, Van Kamp GJ, Barkhof F, Scheltens P. CSF and MRI markers independently contribute to the diagnosis of Alzheimer's disease. Neurobiol Aging. 2007 Jan 4;
Staekenborg SS, van der Flier WM, van Straaten EC, Lane R, Barkhof F, Scheltens P. Neurological Signs in Relation to Type of Cerebrovascular Disease in Vascular Dementia. Stroke. 2008 Feb;39(2):317-22.
Staekenborg SS, Gillissen F, Romkes R, Pijnenburg YA, Barkhof F, Scheltens P, van der Flier WM. Behavioural and psychological symptoms are not related to white matter hyperintensities and medial temporal lobe atrophy in Alzheimer's disease. Int J Geriatr Psychiatry. 2008 Apr;23(4):387-92
Karas G, Sluimer J, Goekoop R, van der Flier W, Rombouts SA, Vrenken H, Scheltens P, Fox N, Barkhof F. AJNR Am J Neuroradiol. 2008 May;29(5):944-9.
Amnestic mild cognitive impairment: structural MR imaging findings predictive of conversion to Alzheimer disease.
Sluimer JD, van der Flier WM, Karas GB, Fox NC, Scheltens P, Barkhof F, Vrenken H.
Whole-brain atrophy rate and cognitive decline: longitudinal MR study of memory clinic patients. Radiology. 2008 Aug;248(2):590-8.
Sluimer JD, Vrenken H, Blankenstein MA, Fox NC, Scheltens P, Barkhof F, van der Flier WM.
Whole-brain atrophy rate in Alzheimer disease: identifying fast progressors. Neurology. 2008 May 6;70(19 Pt 2):1836-41.
Sluimer JD, Bouwman FH, Vrenken H, Blankenstein MA, Barkhof F, van der Flier WM, Scheltens P. Whole-brain atrophy rate and CSF biomarker levels in MCI and AD: A longitudinal study. Neurobiol Aging. 2008 Aug 7.
Gouw AA, Seewann A, Vrenken H, van der Flier WM, Rozemuller JM, Barkhof F, Scheltens P, and Geurts JJ. Heterogeneity of white matter hyperintensities in Alzheimer's disease: post-mortem quantitative MRI and neuropathology. Brain 2008; 131: 3286-3298.
Sluimer JD, van der Flier WM, Karas GB, van Schijndel R, Barnes J, Boyes RG, Cover KS, Olabarriaga SD, Fox NC, Scheltens P, Vrenken H, Barkhof F.
Accelerating regional atrophy rates in the progression from normal aging to Alzheimer's disease. Eur Radiol. 2009 Dec;19(12):2826-33. Epub 2009 Jul 18.
Henneman WJ, Sluimer JD, Barnes J, van der Flier WM, Sluimer IC, Fox NC, Scheltens P, Vrenken H, Barkhof F.
Hippocampal atrophy rates in Alzheimer disease: added value over whole brain volume measures. Neurology. 2009 Mar 17;72(11):999-1007.
Henneman WJ, Sluimer JD, Cordonnier C, Baak MM, Scheltens P, Barkhof F, van der Flier WM.
MRI biomarkers of vascular damage and atrophy predicting mortality in a memory clinic population. Stroke. 2009 Feb;40(2):492-8.
WJ Henneman, H Vrenken, J Barnes, IC Sluimer, NA Verwey, MA Blankenstein, M Klein, NC Fox, P Scheltens, F Barkhof, and WM van der Flier. Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease. Neurology 2009; 73: 935-940.
Goos JD, Henneman WJ, Sluimer JD, Vrenken H, Sluimer IC, Barkhof F, Blankenstein MA, Scheltens PH, van der Flier WM. Incidence of cerebral microbleeds: a longitudinal study in a memory clinic population. Neurology 2010 Jun 15;74(24):1954-60.