Irma van Die

Glycobiology and immune regulation  

Recent studies indicate that glycan moieties within glycoconjugates and their lectin receptors are critically involved in communication within the immune system and in the dynamic interaction between the immune system and many pathogens. Our research is focused on understanding glycobiological processes in relation to human diseases, with a special interest on the identification of helminth glycans in protection to inflammatory diseases such as multiple sclerosis and inflammatory bowel disease.

Key Publications

Laan LC, Williams AR, Stavenhagen K, Giera M, Kooij G, Vlasakov I, Kalay H, Kringel H, Thamsborg SM, Wuhrer M, Dijkstra CD, Cummings RD, van Die I. The whipworm Trichuris suis secretes prostaglandin E2 to suppress pro-inflammatory properties in human dendritic cells. FASEB J. 2016 Nov 2. [Epub ahead of print]; PMID: 27806992

Hoeksema MA, Laan LC, Postma J, Cummings RD, de Winther MPJ, Dijkstra CD, van Die I, Kooij G (2016). Treatment with Trichuris suis soluble products during monocyte-to-macrophage differentiation reduces inflammatory responses through epigenetic remodeling. FASEB J 30(8): 2826-2836

Klaver EJ, Kuijk LM, Lindhorst TK, Cummings RD and Van Die I. Schistosoma mansoni soluble egg antigens induce expression of the negative regulators SOCS1 and SHP1 in human dendritic cells via interaction with the mannose receptor (2015). PLoS ONE 10(4): e0124089.

Maftouh M, Belo AI, Avan A, Funel N, Peters GJ, Giovannetti E, van Die  I.  Galectin-4 expression is associated with reduced lymph node metastasis and modulation of Wnt/?-catenin signaling in pancreatic adenocarcinoma. Oncotarget , 5: 5335-49, 2014.

Meyer S, van Liempt E, Imberty A, van Kooyk Y, Geyer H, Geyer R, van Die I. DC-SIGN mediates binding of dendritic cells to authentic pseudo-LewisY glycolipids of Schistosoma mansoni cercariae, he first parasite-specific ligand of DC-SIGN. J Biol Chem , 280: 37349-59, 2005.

Overview of publications of Irma van Die Group:

Contact details: E, Ph: 020 4448157