Joke den Haan

Myeloid cells in Adaptive Immunity

The adaptive immune response starts with the uptake of antigens by different types of antigen presenting cells such as dendritic cells and macrophages and the subsequent presentation of these antigens to T and B cells. In our group we study different types of macrophages and DCs that are present in lymphoid organs and how they can activate immune responses. Previously, we discovered an unique role for mouse CD8+ dendritic cells in the cross-presentation of antigens to CD8+ T cells. Currently, our studies focus on antigen uptake by CD169+ macrophages and the transfer to dendritic cells and B cells. Our aim is to use this knowledge to generate new types of vaccines to generate strong immune responses against cancers such as melanoma. 

Key publications

Veninga,H., E.G.Borg, K.Vreeman, P.R.Taylor, H.Kalay, K.Y.van, G.Kraal, L.Martinez-Pomares, and J.M.den Haan. 2015. Antigen targeting reveals splenic CD169 macrophages as promoters of germinal center B-cell responses. Eur J Immunol. 45:747-757.

Beijer,M.R., R.Molenaar, G.Goverse, R.E.Mebius, G.Kraal, and J.M.M.den Haan. 2013. A crucial role for retinoic acid in the development of Notch-dependent murine splenic CD4-CD8- and CD4+ dendritic cells. Eur J Immunol 43:1608-1616.

den Haan,J.M.M. and L.Martinez-Pomares. 2013. Macrophage heterogeneity in lymphoid tissues. Seminars in Immunopathology 35:541-552.

Backer,R., T. Schwandt, M. Greuter, M. Oosting, F. Jungerkes, T. Tuting, L. Boon, T. O'Toole, G. Kraal, A. Limmer, and J. M. den Haan. 2010. Effective collaboration between marginal metallophilic macrophages and CD8+ dendritic cells in the generation of cytotoxic T cells. Proc Natl Acad Sci USA 107:216.

den Haan,J. M., S. M. Lehar, and M. J. Bevan. 2000. CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo. J Exp Med 192:1685.

Contact details: Email; Phone 020-4448058