Elga de Vries

The neurovascular unit in health and disease          

A number of neurological diseases are marked by the occurrence of inflammatory and oxidative-stress related events in the vasculature of the central nervous system (CNS). The research of the De Vries group is therefore focussed on understanding how alterations at the neurovascular unit underlie neuroinflammatory and neurodegenerative conditions to find novel ways to counteract these detrimental processes.
Pathological alterations in the integrity and function of the brain vasculature and its surrounding cell types are observed in a wide range of neurological diseases such as multiple sclerosis, stroke, brain cancer, and vascular dementia. Current research focuses on the alterations of the neurovascular unit  in MS and a form of dementia which is marked by amyloid deposits at the brain vasculature, capillary cerebral amyloid angiopathy (capCAA) and how this affects brain homeostasis.

Key Publications HE de Vries

Kamphuis WW, de Vries HE. Studying the blood-brain barrier will provide new insights into neurodegeneration - YesMult Scler. 2018 Mar 1:1352458518754367

Derada Troletti C, Lopes Pinheiro MA, Charabati M, Gowing E2, van Het Hof B1, van der Pol SMA, Geerts D, Prat A, Fontijn RD, Unger WW, de Vries HE. Notch signaling is impaired during inflammation in a Lunatic Fringe-dependent manner. Brain Behav Immun. 2018 Mar;69:48-56. doi: 10.1016/j.bbi.2017.12.016. Epub 2017 Dec 28.

Lopes Pinheiro MA, Garcia-Vallejo JJ, van het Hof B, Wierts L, O'Toole T, Verstege M, van der Pol SM, van Kooyk Y, de Vries HE, Unger WW. Uptake, processing and presentation of myelin-derived antigens by brain endothelial cells facilitates antigen-specific T cell migration. Elife Sciences: 2016;5:e13149. DOI: 10.7554/eLife.13149

Mizee MR, Nijland PG, van der Pol SM, Drexhage JA, van Het Hof B, Mebius R, van der Valk P, van Horssen J, Reijerkerk A, de Vries HE. Astrocyte-derived retinoic acid: a novel regulator of blood-brain barrier function in multiple sclerosis. ACTA Neuropathologica 2014 128:691-703

Kooij G, Kopplin K, Blasig R, Stuiver M, Koning N, Goverse G, van der Pol SM, van Het Hof B, Gollasch M, Drexhage JA, Reijerkerk A, Meij IC, Mebius R, Willnow TE, Müller D, Blasig IE, de Vries HE. Disturbed function of the blood-cerebrospinal fluid barrier aggravates neuro-inflammation. ACTA Neuropathol 2014;128:267-277.

Carrano A, Snkhchyan H, Kooij G, van der Pol S, van Horssen J, Veerhuis R, Hoozemans J, Rozemuller A, de Vries HE. ABC transporters P-gp and BCRP are reduced in capillary cerebral amyloid angiopathy. Neurobiol Aging. 2014;35:565-75

Reijerkerk A, Lopez-Ramirez MA, van Het Hof B, Drexhage JA, Kamphuis WW, Kooij G, Vos JB, van der Pouw Kraan TC, van Zonneveld AJ, Horrevoets AJ, Prat A, Romero IA, de Vries HE. MicroRNAs at the inflamed brain endothelial cell barrier, implications for multiple sclerosis. J Neuroscience 2013, 33:6857-6863

Overview of publications of Elga de Vries Group: http://www.ncbi.nlm.nih.gov/pubmed/?term=de+vries+he

Contact details: Email he.devries@vumc.nl; Phone 020-4448077