Jack van Horssen

Immunohistopathological aspects of multiple sclerosis
Key histopathological features of multiple sclerosis (MS) include inflammation-driven demyelination, neurodegeneration and astroglial scar formation. These distinctive hallmarks of MS occur focally and diffusely throughout the white and grey matter. Through our collaboration with the Netherlands Brain Bank and the dept. of Neuropathology we have access to a unique collection of well-characterized MS brain tissues from different brain regions. The availability of MS lesion samples allows us to investigate ongoing pathological processes that are involved in MS lesion formation and progression. The main goal of our research group is to identify and understand the mechanisms that drive neurodegeneration in MS with a focus on the role of inflammation-mediated oxidative stress and mitochondrial dysfunction. Insight into these pathological processes might lead to the development of novel therapeutics aimed at restoring the delicate brain redox balance and improving mitochondrial function.

Key research publications van Horssen

P.G. Nijland, R.J. Molenaar, S.M. van der Pol, P. van der Valk, C.J. van Noorden, H.E. de Vries, J. van Horssen. Differential expression of glucose-metabolizing enzymes in multiple sclerosis lesions. Acta Neuropathol Commun. 2015, 1:79

P.G. Nijland, M.E. Witte, B. van Het Hof, S. van der Pol, J. Bauer, H. Lassmann, P. van der Valk, H.E. de Vries, J. van Horssen. Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosis.Acta Neuropathol. Commun. 2014 1:170

P.G. Nijland, I. Michailidou, M.E. Witte, M.R. Mizee, S.M. van der Pol, B. van Het Hof, A. Reijerkerk, L. Pellerin, P. van der Valk, H.E. de Vries, J. van Horssen. Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions. Glia 2014, 7:1125-41.

M.E. Witte, P.G. Nijland, J.A. Drexhage, W. Gerritsen, D. Geerts, B. van het Hof, A. Reijerkerk, H.E. de Vries, P. van der Valk, J. van Horssen. Reduced expression of PGC-1alpha partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex. Acta Neuropathol. 2013, 2:231-243

M.T. Fischer, R. Sharma, J.L. Lim, L. Haider, J.M. Frischer, D. Mahad, M. Bradl, J. van Horssen* and H. Lassmann*. NADPH Oxidase Expression in Active Multiple Sclerosis Lesions in Relation to Oxidative Tissue Damage and Mitochondrial Injury. Brain 2012, 135:886-99

Key review publications van Horssen

M.E. Witte, D.J. Mahad, H. Lassmann, J. van Horssen. Mitochondrial dysfunction contributes to neurodegeneration in multiple sclerosis. Trends Mol. Med. 2014, 3:179-187.

H. Lassmann*, J. van Horssen*, D. Mahad*. Progressive multiple sclerosis: Pathology and mechanisms of tissue injury. Nature Rev. Neurol. 2012, 11:647-56

Contact details: Email j.vanhorssen@vumc.nl; Phone 020-4448078