Jan Van den Bossche

Translational Macrophage Immunometabolism  

Our research aims to explain how metabolic reprogramming regulates macrophage subsets in different settings, focusing on cancer and cardiovascular disease. By unravelling key questions in macrophage immunometabolism, our overall goal is to demonstrate whether and how targeting macrophage metabolism could be used for future therapy.

Metabolic rewiring in macrophage subsets
(source: Van den Bossche, O'Neill & Menon, Trends in Immunology, 2017)

Key publications

Van den Bossche J, van der Windt GJW. Fatty acid oxidation in macrophages and T cells; time for reassessment? Cell Metabolism. 2018

Baardman J, Verberk SGS, Prange KHM, van Weeghel M, van der Velden S, Ryan DG, Wüst RCI, Neele AE, Speijer D, Denis SW, Witte ME, Houtkooper RH, O'neill LA, Knatko EV, Dinkova-Kostova AT, Lutgens E, de Winther MPJ, Van den Bossche J. A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia. Cell Reports. 2018 Nov 20

J. Van den Bossche, L. A. O'Neill, and D. Menon. Macrophage Immunometabolism; Where Are We (Going)? Trends in Immunology, 2017 Apr 7.                 

Van den Bossche J, Baardman J, Otto NA, van der Velden S, Neele AE, van den Berg SM, Luque-Martin R, Chen HJ, Boshuizen MC, Ahmed M, Hoeksema MA, de Vos AF, de Winther MP. Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages. Cell Reports. 2016 Oct 11.  

Van den Bossche J, Bogaert P, van Hengel J, Guérin CJ, Berx G, Movahedi K, Van den Bergh R, Pereira-Fernandes A, Geuns JM, Pircher H, Dorny P, Grooten J, De Baetselier P, Van Ginderachter JA. Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes. Blood. 2009 Nov 19;114(21):4664-74.              

Contact details: E-mail: j.vandenbossche@vumc.nl | phone: +31 20 4441425
Secretariaat: secretariaat.mcbi@vumc.nl | phone +31 20 444 8080